七年后，Mousekewitz家族定居在它们的新家—纽约的布朗克斯区，贫困的它们发现，情况并不如理想，因为它们依然要努力对抗袭击老鼠的饿猫。伟福幻想与西部的威利警长度日，姐姐丹霞梦想成为一位歌手；同时泰加的女友咪咪厌倦了做一只野猫，要在西部寻找新生活，道出她希望寻找一只“像狗一样”的猫。

  Some time after the Mousekewitz's have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan. Unaware of this, the Mousekewitz's begin their journey west, while their true cat friend, Tiger, follows intent on following his girlfriend gone in the same direction.